Without mouse clicks, I cannot re-install Guest Additions to try to clear the issue caused by the Input>Mouse Integration button (not sure GA re-install would work even if I could). The right mouse click does seem to work for changing the Win 10 desktop screen resolution, etc, but not on icons. Re-clicking the 'Mouse Integration' icon on the 'Input' menu has no effect. But, as I said, the mouse moves smoothly inside the virtual desktop and across to my host desktop, so it doesn't seem to be captured, and the Right Ctrl key has no effect. The cursor moves smoothly between the guest machine desktop window and the host desktop, and I frequently get the popup message about the captured mouse: 'You have clicked the mouse inside the Virtual Machine or pressed the host key', telling me to look in the lower right corner of the guest screen for the host key to use to uncapture the mouse (Right Ctrl). Thereafter I have been unable to click on anything on the guest desktop. Made the mistake of browsing through the menus at the top of the screen, clicked on the 'Input' tab, then inadvertently clicked the 'Mouse Integration' icon, thinking it was a menu tab. It runs on a Windows 10 host using VBox 5.2.22 with corresponding Guest Additions installed on the guest. I have a Windows 10 guest, recently installed and tailored after I had to replace a failed hard drive.

Help! I can't click the mouse in my Win 10 guest!

Windows 10 cannot click on anything